I’ve learned over the years that everything is more or less the same amount of work, so you may as well set your sights high and try and do something really cool.
There are other people around who can do the mediocre, meat-and-potatoes work that anybody can do. So let them do that. You make the art that only you can make. You tell the stories only you can tell.
As a solution to various problems you may encounter upon the way, let me suggest this:
Make Good Art.
It’s very simple. But it seems to work. Life fallen apart? Make good art. True love ran off with the milkman? Make good art. Bank foreclosing? Make good art.
Keep moving, learn new skills.
— Neil Gaiman